![]() These individuals reacted with stronger antibody and T-cell responses to the vaccine doses than uninfected people. This means that up to 85% of people in some regions have hybrid immunity.Įarlier hybrid immunity was elicited chiefly by Alpha or earlier variants of the virus, also called ancestral variants. However, the risk of symptomatic coronavirus disease 2019 (COVID-19) has been reduced by 67% at 2-4 weeks from the third dose but less than 50% at ten weeks or later. Omicron is remarkable for the very large number of spike mutations that led to its evasion of vaccine- and infection-induced immunity.Īt present, three doses of a messenger ribonucleic acid (mRNA) vaccine are recommended for protection against adverse outcomes following SARS-CoV-2 infection. The currently circulating variants include BA.2.75, BQ.1, and XXB. The Omicron variant rapidly mutated into several sublineages, from BA.1/BA.2 to BA.4/5. Image Credit: Fit Ztudio/ShutterstockĪ new study looked at the whole spectrum of immunological reactions raised by spike and non-spike antigens following Omicron BA.1/BA.2 infections in such individuals, both with and without prior SARS-CoV-2 infection. Study: Omicron BA.1/BA.2 infections in triple-vaccinated individuals enhance a diverse repertoire of mucosal and blood immune responses. Serological studies indicated this was associated with suboptimal immune reactions in triple-vaccinated people. It caused large numbers of breakthrough infections even in those people who had hybrid immunity (“generated through a combination of vaccination and infection”). The Omicron variant of concern (VOC) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread rapidly, displacing earlier variants worldwide. *Important notice: medRxiv publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be regarded as conclusive, guide clinical practice/health-related behavior, or treated as established information. Liji Thomas, MD Reviewed by Aimee Molineux ![]()
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