Objective To assess the anti-aggressive effects of the 5-HT1B receptor agonist CP-94,253 when microinjected into the VO PFC (0.1, 0.56, and 1.0 μg/0.2 μl) or into the infralimbic prefrontal cortex (IL PFC 1.0 μg/0.2 μl) in separate groups of aggressive resident male mice. One site of action for these drugs is the 5-HT1B receptors in the ventral orbitofrontal cortex (VO PFC), an area that has been implicated in the inhibitory control of behavior and is a terminal region for 5-HT projections. Rationale Systemic injections of 5-HT1B receptor agonists have been shown to have specific anti-aggressive effects in aggressive individuals. CS administration also exerted an increased anxiogenic-like behavior, which was normalized only by the local infusion of the GR antagonist.Based on these findings, we suggest that CS secreted by emotionally relevant stimuli acting via GR in LS plays an important role in the modulation of the emotional sequelae induced by social defeat. Moreover, we explored the effect of local infusions of MR or GR antagonists into the LS on the behavior exhibited by CS-treated rats in a subsequent EPM exposure. Only the administration of the GR antagonist, but not the MR antagonist, into the LS normalized the anxiogenic response induced by defeat.Furthermore, we examined whether a single injection of corticosterone (CS) could induce the same influence on the behavior in the EPM as that observed after social defeat. All rats were tested in the EPM 1 day later. Intruder animals were infused into the LS with the MR or GR antagonist (ZK 91587 and RU 38486, respectively) and then submitted to social stress. The LS is an area of the aversive circuitry that is preferentially activated in passive defensive postures, and participates – together with other brain areas – in the modulation of aversive states. One day after defeat, intruder animals exhibited an anxiogenic-like behavior in the EPM.In addition, we also evaluated the role of the corticosteroid receptor system (minerlocorticoid – MR – and glucocorticoid – GR – receptors) from the lateral septum (LS) on the anxiety generated by social defeat. Thank you.The current research studied the behavior adopted in the elevated plus maze (EPM) of rats previously subjected to a social defeat using the resident-intruder paradigm. If you need/want to use info from our profile, please kindly put a link to this post. Please do respect the time and effort the author put in compiling this profile. Note: Please don’t copy-paste the content of this page to other sites/places on the web. He is a current contestant on Boys Planet. He doesn’t drink coffee, so when he goes to Starbucks, he gets the closest thing to a milkshake. Jay sang the USA National Anthem for the NBA Mavericks v. He did a USA tour with FM Trainee, Beomhan. His mom is Filipino-Chinese and his dad is Irish-Hungarian. Beast’s 100 people in a circle challenge and won a PS5, which he prefers over Xbox. – His two favorite Pokémon are Sirfetch’d and Psyduck. – Jay mentioned that his favorite type of weather is cloudy with no rain. – He likes a lot of early 2000-2010 rock music. – His favorite book is Stone Fox, it is the reason his favorite breed of dog is a Husky. – When he was younger, he really liked the Slenderman creepypasta and the YouTube creator Markiplier. – His favorite colors are yellow and crimson red. – He plays guitar and has played drums since he was 3 years old. – When asked about his favorite movie genre, he said it was horror and recommended “Children of the Corn”. – His favorite animes are Kuroko’s Basketball and Demonslayer. – His current favorite song is “Japanese Denim” by Daniel Ceasar, (Updated 12/31/22 Boys Planet profile). His role models are Taeyang and Crush (Boys Planet profile). – He attended Hasbrouck Heights High School (LinkedIn) – He is from New Jersey, USA (according to Jay).
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